Lead author of the study, David A. Sinclair, a Harvard Medical School professor and co-founder of the Cambridge biotechnology company Sirtris Pharmaceuticals Inc, Cambridge, United States, believes that cells’ decreasing ability to detect patterns of gene expression plays a key role in aging. Sirtris Pharmaceuticals is known for its development of an experimental drug called resveratrol.
The study author said that during the process of aging, cells have more difficulty understanding which genes
define are switched 'on' and which are switched 'off' in a particular setting.
Prof. Sinclair said, "What this paper actually implies is that aspects of aging may be reversible." Adding further he said, "It sounds crazy, but in principle it should be possible to restore the youthful set of genes, the patterns that are on and off."
Researchers have known for quite sometime that sirtuins, the group of proteins that may be able to control age-related disorders in mammals, are involved in the aging process. SIRT1 is the member of this class of enzymes and is currently the most studied of the group. Prof. Sinclair wrote in the paper that sirtuins help maintain a youthful pattern of gene expression by ensuring that the genes that should be “off” remain silent.
When SIRT1 is stimulated by either the red-wine chemical resveratrol or caloric restriction, it appears to have a positive effect on both aging and health, the researchers reported in journal Cell. Professor Sinclair has been taking large daily doses of resveratrol since he and others discovered five years ago that it activated sirtuin.
“I’m still taking it, and I feel great,” he said, “but it’s too early to say if I’m young for my age.”
Sirtris Pharmaceuticals Inc is trying to use drugs based on an extract in red wine to fight Type 2 Diabetesdefine and other age-related diseases. Sirtris is also engaged in human clinical trials for type 2 Diabetes and MELAS, a mitochondrial disorder.
Natural Resveratrol Supplements are available now..
Resveratrol can help you to lead a long and healthy life so says Dr. Oz.
Red wine alone does not supply enough resveratrol to achieve the
full range of benefits because one glass of red wine has only about
1mg of resveratrol and you need about 250mg/day. You need to take
high potency resveratrol supplements to achieve the results documented
in scientific studies.Resveratrol Supplements can also help you control
your weight naturally by increasing energy, reducing cravings, and limiting
your appetite.According to Wikipedia, Consumer Lab, an independent dietary
supplement and over the counter products evaluation organization,
published a report on 13 November 2007 on the popular resveratrol
supplements. The organization reported that there exists a wide range
in quality, dose, and price among the 13 resveratrol products
evaluated. The actual amount of resveratrol contained in the
different brands range from 2.2mg for Revatrol, which claimed to have
400mg of "Red Wine Grape Complex", to 500mg for Biotivia.com Transmax,
which is consistent with the amount claimed on the product's label.
Prices per 100mg of resveratrol ranged from less than $.30 for
products made by Biotivia.com, jarrow, and country life, to a high of
$45.27 for the Revatrol brand.
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